Lezing 'Role of IRG1 in the host immune response to restrict Mycobacterium tuberculosis infection'

Voor wie
Bedrijven , Medewerkers , Studenten
03-06-2022 van 11:30 tot 12:30
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
Door wie
VIB-UGent Center for Inflammation Research

How can rewiring the Krebs cycle limit the replication and spreading of Mycobacterium tuberculosis?

Eik Hoffmann (Pasteur Institute Lille, Center for Infection and Immunity of Lille (CIIL), Lille, France) is our guest speaker. Mycobacterium tuberculosis (Mtb), the pathogen causing human tuberculosis, has evolved multiple strategies to successfully prevent clearance by immune cells and to establish dissemination and long-term survival in the host. The modulation of host immunity to maximize pathogen elimination while minimizing inflammation-mediated tissue damage may provide another tool to fight drug-resistant Mtb strains. Our results provide evidence how rewiring of the TCA cycle confines the host response to Mtb via the IRG1/itaconate axis to restrict replication and dissemination of this pathogen.

Registration for this talk is not required. Online attending is possible.