Lezing 'Molecular basis of cell death-driven inflammation'

Programmed cell death (PCD) controls the elimination of unnecessary, damaged, malignant, or infected cells during development and tissue homeostasis. Apoptosis—the best-studied form of PCD—leads to the disintegration of dying cells into apoptotic bodies that maintain membrane integrity and are removed by phagocytes in an immunologically silent manner. In contrast to apoptosis, programmed necrotic cell death, such as pyroptosis and necroptosis, results in cell lysis, which drives inflammation and immune responses. While the molecular basis of cell death signaling has been explored, very little is still known about how different forms of PCD are sensed, and what molecules are released by different forms of PCD. Here we will discuss new insights into this questions, as well as the molecular drivers of cell lysis.

Registration for this presentation is not required. Online attending is also possible.