Novel methods for Clostridium perfringens isolation and NetB toxin quantification, the causative agent of necrotic enteritis in broiler chickens

Husta, Martina
Faculteit Diergeneeskunde
Vakgroep Pathobiologie, Farmacologie en Bijzondere Dieren
Martina Hustá was born on the 8th of April 1989 in Stuttgart, Germany. After finishing her Gymnasium in Stuttgart and a year aborad in Australia, Martina started a course for a Biotechnological Lab Assistant, which she finished in 2011. The same year, she started studying Biology at the Eberhard Karls University in Tübingen, Germany. In 2017, she finished her Master of Science in Microbiology. Martina then moved from Germany to Belgium to start her PhD about necrotic enteritis in poultry, at the Livestock Gut Health Team. Since July 2022 she works as a Scientific Support Specialist at Abcam, in Amsterdam, The Netherlands. Martina is the author of different scientific publications in international journals.
Academische graad
Doctor in de diergeneeskundige wetenschappen
Taal proefschrift
Prof. dr. Filip Van Immerseel, Faculty of Veterinary Medicine, UGent - Dr. Evy Goossens, Faculty of Veterinary Medicine, UGent

Korte beschrijving

Necrotic enteritis (NE) is one the most important diseases in poultry industry with global annual costs exceeding US$ 6 billion. NE mostly occurs in broiler chickens and is caused by pathogenic Clostridium perfringens type G strains, which, when the environment is favourable, proliferate in the chicken intestine and induce disease. NE can present itself as an acute, clinical form or as a subclinical, chronic form, of which the latter is more prevalent. However, in both forms, C. perfringens causes lesions in the small intestine, mostly found in the jejunum. Although the pathogenesis has been extensively studied, the whole sequence of events and factors involved is still not fully understood. Nevertheless, studies have identified the necrotic enteritis B-like (NetB) toxin as a key toxin in NE in broilers. Diagnostic tools are important when it comes to studying infectious diseases and its causative agents, but also for accurate diagnosis and subsequent treatment.


Dinsdag 20 september 2022, 17:00
Diergeneeskunde Aud Maximum, Salisburylaan 133, 9820 Merelbeke

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