Curcumin and fish oil as natural anti-inflammatory compounds in Holstein neonatal calves: a metabolomics approach

Kameloroumieh, Saeid
Faculteit Diergeneeskunde
Vakgroep Translationele Fysiologie, Infectiologie en Volksgezondheid
Saeid Kameloroumieh was born on January 4, 1988, in Iran. In 2007, he obtained his BSc in Animal Science at Ferdowsi University of Mashhad, Iran. Subsequently, in 2011 he performed research on nutrition in Holstein Dairy cows, to obtain his MSc degree from the Department of Animal Science at Ferdowsi University of Mashhad. He started his Ph.D. on the effect of natural compounds on calf feces metabolome at Ghent University in 2019. He is interested in improving livestock productivity, through nutrition and metabolomics research. He is the author of four scientific publications and was a speaker on two symposia while taking an active part in several national and international conferences.
Academische graad
Doctor in de diergeneeskundige wetenschappen
Taal proefschrift
Prof. dr. Lynn Vanhaecke, Faculty of Veterinary Medicine, UGent - Prof. Dr. Lieven Van Meulebroek, Faculty of Veterinary Medicine, UGent
Prof. dr. Siska Croubels, Faculty of Veterinary Medicine, UGent - Prof. dr. Bert Devriendt, Faculty of Veterinary Medicine, UGent - Prof. dr. Bart Pardon, Faculty of Veterinary Medicine, UGent - Dr. Leen Vandaele, Instituut voor Landbouw-, Visserij- en Voedingsonderzoek, ILVO - Prof. dr. Geert Opsomer, Faculty of Veterinary Medicine, UGent - Dr. Nathalie De Clercq, Thermo Fisher Scientific, Breda

Korte beschrijving

Calf mortality is a critical cause of economic loss in the dairy cow industry. In this regard, gram-negative bacteria are one of the most pathogenic agents which are common in calf diseases and have a significant effect on the health status of calves. Complementary and alternative medicines (CAM) may improve enteric disease resistance. Popular CAM therapies include amongst other herbs (e.g., cannabis, Chinese medicine, and curcumin), vitamins, probiotics, and fatty acids. Curcumin (CUR) is particularly promising because it has been ascribed antioxidant, anti-inflammatory, cancer chemo-preventive, and potential chemotherapeutic properties. In addition, feeding diets containing marine n-3 PUFA may be beneficial for calf health as well, as it alters the cytokine response and regulation of the inflammatory response, hence affecting the ability of the animal to respond to disease. Due to the speedy pathogenesis of gram-negative bacterial infections in calves, an early overcoming of the infection is critical since late treatment is typically not adequate to alter the outcome of the disease process. In this regard, metabolomics has surfaced in recent years as a promising methodology, reflecting the interactions of genetics with the environment, residing microbial ecosystem, and feeding regime, as such accurately representing the calf’s phenotype. Indeed, metabolomics may support the identification of biomarkers that can be used for disease diagnosis or even risk prediction, as well as to unravel (patho)physiological pathways.


Maandag 8 november 2021, 17:00
Diergeneeskunde aud kliniek A, Salisburylaan 133, 9820 Merelbeke

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