Bernd Vanmeerhaeghe

Bernd










Contact

Bernd Vanmeerhaeghe
Laboratory for General Biochemistry and Physical Pharmacy
Ghent University
Ottergemsesteenweg 110
9000 Gent
Belgium
Tel: 0032 9 264 8047 (secretary)
Tel: 0032 9 933 5051 (direct)

E-mail: bernd.vanmeerhaeghe@ugent.be

 

Biography

Bernd Vanmeerhaeghe started his Bachelor in Pharmaceutical Sciences at Ghent University in 2016, and obtained his master’s degree in Drug Development in 2021 with great distinction. He performed his master thesis at the Laboratory for Clinical Biology (Ghent University Hospital) under the supervision of Prof. Dr. Alain Verstraete where he investigated the relationship between blood and intrapulmonary concentrations of β-lactam antibiotics. In September 2021 he performed a career switch and joined the Laboratory of General Biochemistry and Physical Pharmacy at the Faculty of Pharmaceutical Sciences (Ghent University). Here, he works on the photoporation of corneal endothelial cells under the supervision of Prof. Dr. Apr. Stefaan De Smedt and Dr. Félix Sauvage.

Research Interests

Ocular delivery, nanotechnology, photoporation, Ophthalmology, siRNA

Research

The cornea of the eye is the most frequently transplanted intact tissue in the world. Currently, there is a huge shortage of good corneal grafts with 1 good graft available for every 70 grafts needed. One of the main reasons is the insufficient amount of corneal endothelial cells present on the donor graft. Since these cells assure the deturgescence (partial dehydrated state) of the anterior stroma, insufficient cells result in an impaired vision due to oedema of the stroma. Unfortunately, these cells do not proliferate in vivo, and up to almost half of the cells are lost during surgery. Therefore, we intend to photoporate these cells with the aim to let them proliferate, and ultimately increase the amount of good corneal grafts.