Lecture 'Role of IRG1 in the host immune response to restrict Mycobacterium tuberculosis infection'

For whom
Business , Employees , Students
When
03-06-2022 from 11:30 to 12:30
Where
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
Language
English
Organizer
VIB-UGent Center for Inflammation Research
Contact
Nele.Vanlangenakker@UGent.be
Website
https://www.irc.ugent.be/index.php?id=tocalendar

How can rewiring the Krebs cycle limit the replication and spreading of Mycobacterium tuberculosis?

Eik Hoffmann (Pasteur Institute Lille, Center for Infection and Immunity of Lille (CIIL), Lille, France) is our guest speaker. Mycobacterium tuberculosis (Mtb), the pathogen causing human tuberculosis, has evolved multiple strategies to successfully prevent clearance by immune cells and to establish dissemination and long-term survival in the host. The modulation of host immunity to maximize pathogen elimination while minimizing inflammation-mediated tissue damage may provide another tool to fight drug-resistant Mtb strains. Our results provide evidence how rewiring of the TCA cycle confines the host response to Mtb via the IRG1/itaconate axis to restrict replication and dissemination of this pathogen.

Registration for this talk is not required. Online attending is possible.