Lecture 'Oxygen sensing in health and disease'

For whom
Business , Employees , Students
20-05-2022 from 11:30 to 12:30
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research

Discover how white blood cell migration and the production of corticoids and adrenaline are regulated by low oxygen concentration signalling.

Ben Wielockx (Institute of Clinical Chemistry and Laboratory Medicine, TU Dresden, Germany) is our guest speaker today.

An inappropriate pO2 can lead to profound changes in virtually every cellular response. Oxygen sensing is therefore indispensable as it enables cells in our body to instantaneously adapt to dramatically low oxygen concentrations (hypoxia). Central components of the response to hypoxia are the hypoxia inducible factors (HIF1α and 2α), transcription factors that are directly regulated by oxygen-dependent HIF prolyl-hydroxylase domain enzymes (PHD1-3). Over the past decade, central roles for the PHD-HIFα axis in a variety of physiological and pathological settings, including hematopoiesis, wound healing, bone metabolism and tumor development were unravelled. More recently, we revealed that hypoxia signaling has an important impact on the innate immune response and these results will discussed today.

To join the seminar online, click on the link above.