Laboratory of Pharmacology and Toxicology

Research mission

The main research mission of the Laboratory of Pharmacology and Toxicology (Prof. dr. S. Croubels, Prof. dr. M. Devreese) consists of generating and communicating insights in in vivo ADME processes (absorption, distribution, metabolisation and excretion) and PK/PD modeling of human and veterinary drugs and toxins in a variety of animal species. The Laboratory is OECD GLP compliant for the conduct of in vivo ADME trials, pharmacokinetic modeling, safety studies, and bio-analysis of human and veterinary drugs. The Laboratory has over 20 years of experience in the development of analytical methodologies for the detection and quantification of xenobiotics (drugs, mycotoxins and their metabolites) in different biological samples such as plasma and tissues, using (UHP)LC-MS/MS and HR-LC-MS, and in pharmacokinetic (PK) and toxicokinetic (TK) modeling of these compounds.  The laboratory has 4 (UHP)LC-MS/MS instruments, 1 UHPLC-UV instrument and access to 3 HR-LC-MS instruments.

Doctoral research topics veterinary pharmacology

The research within the veterinary pharmacology group is related to optimization of antmicrobial dosage regimens for reduced resistance selection on the one hand, and the development of a juvenile piglet model as a pediatric preclinical model for PK/PD.

  • Effect of dose and administration route on antimicrobial gut exposure of selected antimicrobials in pigs. PhD candidate Joren De Smet
  • Homogeneity, stability and cross-contamination of drugs mixed in the feed and drinking water for group medication in pigs. PhD candidate Femke Vandael
  • Next generation pharmacokinetic-pharmacodynamic modeling: dosage regimen for both curative and metaphylactic antimicrobial treatment taking antimicrobial resistance development into account – The case of enrofloxacin and avian pathogenic Escherichia coli infections in broiler chickens. PhD candidate Robin Temmerman
  • SAFEPEDRUG: Integrating multidisciplinary translational bottom-up approaches towards a new paradigm for pediatric investigations: the next step in ethical pediatric drug research. PhD candidate Elke Gasthuys
  • An ontogenic piglet model as human pediatric surrogate for preclinical PK and PD drug testing. PhD candidate Joske Millecam
  • A juvenile pig model for pharmacokinetic studies of renally excreted drugs in children with augmented renal clearance. PhD candidate Laura Dhondt
  • Comparing cephalosporins for treatment of severe infections in pigs taking antimicrobial resistance selection into account. PhD candidate Sofie Rutjens
  • Macrocyclic lactones as an additional measure for malaria parasite and vector control in Ethiopia. PhD candidate Gemechu Zeleke Itica Carii
  • Efficacy of NSAIDs for treatment of PDS syndrome in farrowing sows. PhD candidate Alexandra Schoos
  • Development and validation of a juvenile porcine model to study antibiotic tissue pharmacokinetics in pediatric patients with sepsis. PhD candidate Eline Hermans

Doctoral research topics veterinary toxicology

The research within the veterinary toxicology group is related to the mycotoxin problem in livestock. More specifically, bioanalytical method development for quantification in animal matrices; the toxicity, toxicokinetics and residues of (emerging) mycotoxins in livestock; interactions between mycotoxins and pathogens in livestock and models for in vitro and in vivo safety and efficacy testing of mycotoxin detoxifiers. The laboratory is also a member of the interdisciplinary research association group MYTOX.

  • Interaction between Fusarium mycotoxins and cytochrome P450 drug metabolizing enzymes and ABC drug transporters in a porcine animal model. PhD candidate Wim Schelstraete
  • Toxicokinetic study of the modified mycotoxins deoxynivalenol-3-β-D-glucoside, zearalenone-14-glucoside and zearalenone-14-sulfate in the juvenile pig as human paediatric surrogate model. PhD candidate: Amelie Catteuw
  • Study on the interactions between mycotoxins and the rumen, on their possible toxicological effects on the gastrointestinal tract and their intestinal absorption in dairy cattle: an in vitro approach. PhD candidate: Sandra Debevere
  • Biomarkers for exposure of mycotoxins in pigs and broiler chickens, and efficacy of feed additives. PhD candidate: Marianne Lauwers
  • Emerging mycotoxins tenuazonic acid and enniatins: toxicity and toxicokinetics in pigs and poultry. PhD candidate: Sophie Fraeyman
  • The incidence of citrinin in the Belgian food and feed chain and the risk for human and animal health. PhD candidate: Celine Meerpoel
  • Mitigating an amphibian pandemic by embedding biodiversity conservation in contaminant exposed agricultural landscapes. PhD candidate: Tess Goessens